Conference Service Mandl

abstract: The goal of this meeting is to present the most current research on the vasculature by breaking down the blood vessel into individual cells (endothelium, smooth muscle and nerve) and examine the function of organelles (nucleus, ER, plasma membrane) within each cell type. This work will be synthesized into the whole blood vessel, and a focus given to vessel dysfunction in hypertension and—as is highlighted by a concurrent meeting—diabetes. Workshops will support young investigators, and techniques specific to studying the vasculature. Attendees should take away an appreciation for the complexity and beauty of the vasculature.

abstract: It has long been known that the interactions between cells and their respective microenvironments are instructive and necessary in proper development. Cell-environment interactions play complex roles in organ homeostasis and, when altered, disease. Increasing evidence now suggests that the microenvironment also modulates critical aspects of the genesis and progression of tumors. For example, initiation, progression and even control of metastasis and latency are governed by these interactions. This modulation is most likely brought about through both genetic and epigenetic mechanisms. Currently, the signaling pathways and mechanisms of regulation are mostly unknown. This conference will bring together leaders in this field to discuss current problems and strategize on the clinical application of new insights.

abstract: The discovery of evolutionarily conserved immune genes and pathways has led to an explosive discovery phase in innate immunity. These pathways include TLR, NLR, C-type lectin Receptor, and the helicase-containing anti-viral proteins. These novel pathways merge the innate and adaptive branches of immunity, and converge on a wide range of disorders including infectious diseases, inflammation and autoimmunity. All of the above have systemic effects that can affect the outcome of a wide range of diseases ranging from cancer to cardiovascular disorders.