Conference Service Mandl

abstract: A complete understanding of the structure and functions of DNA and chromosomes requires a multi-disciplinary approach. This is particularly true in the post-genomic era. Historically, the use of methods and concepts from physics has led to fundamental progress in biology in general, and towards the structure and function of genetic material in particular. Outstanding problems in biology also often lead to fundamental questions of a physical nature. Thus, new and original concepts often arise from such interdisciplinary approaches. For example, techniques invented to study the physical properties of single molecules, in particular DNA, (elasticity, forces, dynamics, ...) have led to the understanding of interactions with enzymes (topoisomerases, helicases, polymerases, ...) and unveiled new, intermediate reactions. It has also been shown that DNA and RNA polymerases are extremely powerful motors. The three-dimensional structure and the molecular composition of replication, transcription and repair sites is also better understood, thanks to novel microscopy and diffraction techniques. The complete sequencing of genomes and the exploitation of databases of genomic expression also require the development of new mathematical and informational methods.

The aim of this summer school is to favor the development of a multidisciplinary approach to the study of DNA and chromosomes. The school will contribute to the exchange of ideas, techniques and researchers between the different communities which will lead to the emergence and development of new collaborations.