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Konferenzen zum Thema Biochemie und Medizinische Chemie in Kanada

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1.Keystone Symposia: Advances in Hypoxic Signaling: From Bench to Bedside
Termin	12. Feb 2012 → 17. Feb 2012	[ID=427754]
Ort	Banff, Alberta, Kanada
Zusammenfassung	Changes in tissue oxygen levels are frequently associated with pathological conditions such as pulmonary, cardiovascular and neoplastic diseases, but also occur physiologically during development. Recent advances in understanding the molecular basis of cellular and systemic hypoxia responses have led to the discovery of novel therapeutic targets that have the potential to impact the treatment of ischemic and neoplastic diseases. This Keystone Symposia meeting on Advances in Hypoxic Signaling: From Bench to Bedside will provide a state-of-the-art overview and critical discussion of hypoxia research and will serve as a superb platform for scientific exchange between senior and junior investigators, including students. This meeting brings together leading experts in the field of hypoxic signaling and will: 1) discuss the most recent advances in the regulation of cellular and systemic hypoxia responses; 2) examine the role of hypoxia response pathways in embryonic development, tumorigenesis, tissue injury and repair, inflammation and metabolism; and 3) highlight the latest developments in therapeutic targeting of hypoxia response pathways. This meeting aims to further our understanding of the biological response to hypoxia and promote use of this information for therapeutic gain. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Cancer and Metabolism, which will share a keynote address and a plenary session with this meeting.
Themen	Keystone Symposia, Hypoxic Signaling, Hypoxic Signalling, Hypoxia, Organ Systems, Development, Metabolic Diseases, Biochemistry, Cardiovascular
Webseite	http://www.keystonesymposia.org/12Q4
Verwandte Fachgebiete	Biologie; Medizin (allgem.)

2.Keystone Symposia: G Protein-Coupled Receptors: Molecular Mechanisms and Novel Functional Insights
Termin	17. Feb 2012 → 22. Feb 2012	[ID=427720]
Ort	Banff, Alberta, Kanada
Zusammenfassung	The seven transmembrane-spanning G protein-coupled receptors (GPCRs) are the largest superfamily of receptors in the human genome, are involved in virtually all physiological processes and represent the targets for at least 30% of all current medicines. Recent years have witnessed the coalescing of a number of important paradigms, including ligand-biased signaling, allosteric modulation and receptor dimerization, with substantial advances in structural determination, chemical biology and in vivo approaches to studying GPCR function. These developments will undoubtedly have a profound impact on future approaches to GPCR-based drug discovery. This meeting will focus on the interplay between these developments, and how they can be exploited to advance the translational application of cutting-edge GPCR-based research.
Themen	Keystone Symposia, G Protein-Coupled Receptors, Molecular Mechanisms, Novel Functional Insights, Signaling, Signalling, Biochemistry, Drug Discovery, Diagnostics
Webseite	http://www.keystonesymposia.org/12B4
Verwandte Fachgebiete	Pharmakologie und Arzneimittelentwicklung; Medizin (allgem.)

3.Keystone Symposia: NF-kappaB Signaling and Biology: From Bench to Bedside
Termin	18. Mär 2012 → 23. Mär 2012	[ID=427906]
Ort	Whistler, BC, Kanada
Zusammenfassung	The regulation and function of NF-kB have captivated molecular and cellular biologists, as well as immunologists, pathologists and drug developers for many years. Studies of NF-kB and its regulation have taught us many fundamental lessons and principals in basic biological sciences as well as in biomedicine. Although rapidly reaching maturity, with 25 years since its discovery, the NF-kB field remains vibrant and fertile, and never ceases to amaze with new groundbreaking discoveries. The Keystone Symposia meeting on NF-kB Signaling and Biology: From Bench to Bedside will cover the basic biochemistry of NF-kB signaling; how NF-kkB accomplishes its main job as a transcription factor; the roles of the NF-kB system in immunity and inflammation; how NF-kB controls cell death, survival and metabolism; and how all of these functions go awry during disease development ? something that we have learned both from studies of genetically altered mice and from studies of human genetic defects and pathology. Finally, this meeting will teach us how we might fix and cure these problems through the pharmacological targeting of the NF-kB system. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Ubiquitin Signaling, which will share a keynote address and three plenary sessions with this meeting.
Themen	Keystone Symposia, NF-êB, NF-kappaB, Signaling, Biology, Biochemistry, newly identified cofactors in linking different signaling pathways
Webseite	http://www.keystonesymposia.org/12X1
Verwandte Fachgebiete	Biologie; Medizin (allgem.)
4.Keystone Symposia: Ubiquitin Signaling
Termin	18. Mär 2012 → 23. Mär 2012	[ID=427861]
Ort	Whistler, BC, Kanada
Zusammenfassung	Post-translational modifications of cellular proteins by ubiquitin and ubiquitin-like modifiers regulate a variety of functions in the cell. A crucial aspect of signaling through ubiquitin and Ubls is the presence of modular binding domains that recognize particular types of ubiquitin signals. Such molecular coupling creates an attractive ?decoding? mechanism for responding to alterations in the cellular microenvironment and regulating physiological and pathophysiological conditions. In this meeting, we will discuss the major challenges in the field including detection of endogenous ubiquitination events, functional aspects of novel types of ubiquitin chains and their recognition by selective binding domains, and high-throughput technologies for comprehensive analysis of Ub modifications. The intersection between the deregulated ubiquitin signaling, pathogenesis of human diseases and therapies targeting the Ub system will be explored. The program offers a possibility for young scientists to present their own work and engage in discussions on the emerging topics in the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on NF-kB Signaling and Biology: From Bench to Bedside, which will share a keynote address and three plenary sessions with this meeting.
Themen	Signaling, Inflammation, Immunology, Biochemistry, Keystone Symposia, Ubiquitin Signaling, NF-kappaB, NF-kB, Whistler, British Columbia, Canada
Webseite	http://www.keystonesymposia.org/12X2
Verwandte Fachgebiete	Medizin (allgem.); Biologie
5.Keystone Symposia: Cell Death Pathways: Beyond Apoptosis
Termin	19. Mär 2012 → 24. Mär 2012	[ID=427924]
Ort	Banff, AB, Kanada
Zusammenfassung	Mounting evidence indicates that cell death in diseases results from complex interactions between molecular mechanisms taking place within the degenerating cells (cell-autonomous) and outside the degenerating cells (non-cell autonomous). At the cross roads of these diverse signaling pathways are found the mitochondria which, through proper mitochondrial dynamics and regulated mitochondrial elimination by autophagy (i.e., mitophagy), play a crucial role in maintaining the well-being of the cells. This meeting will focus on the general mechanisms of cell death including the Bcl-2 family and caspase proteases, the role of mitochondrial dynamics and mitophagy, the usefulness of bioinformatics to unravel death-pathways, the contribution of non-cell autonomous mechanisms to cell death and the therapeutic strategies to protect against cell death. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mitochondrial Dynamics and Function, which will share a keynote address and two plenary sessions with this meeting.
Themen	Keystone Symposia, Cell Death Pathways, Apoptosis, pathogenesis, tumor, immunology, Neurodegenerative Disease, Neurobiology, Signaling, Biochemistry, Basic mechanisms, cancer
Webseite	http://www.keystonesymposia.org/12X4
Verwandte Fachgebiete	Biologie; Medizin (allgem.)
6.Keystone Symposia: Cell Biology of Virus Entry, Replication and Pathogenesis
Termin	26. Mär 2012 → 31. Mär 2012	[ID=427930]
Ort	Whistler, BC, Kanada
Zusammenfassung	This meeting will highlight recent advances in virus infection pathways, and in the cellular responses to viral infection. The meeting features multiple stages of the viral lifecycle analyzed using a broad array of techniques and levels of analysis. A novel feature of this meeting is that it will be held concurrently with the Keystone Symposia meeting on Frontiers in HIV Pathogenesis, Therapy and Eradication and will, therefore, focus on maximizing exchange between the HIV community and the broader community of virologists. An explicit goal is to bring together and promote potential synergies among researchers who might not otherwise interact in more specialized meetings. A classic, almost paradigmatic, example of the power of this cross-talk is the contribution of studies of influenza A virus hemagglutinin to our understanding of the HIV-1 entry process, and the subsequent contribution of both systems to our understanding of type I fusion, type II fusion and the entry processes of non-enveloped viruses. Accordingly, two common sessions will focus on the retroviral entry process and its inhibition, followed by talks featuring a broader survey of viral entry, replication, structural and systems approaches to virology, host immune evasion and therapeutics.
Themen	Keystone Symposia, Cell, Biology, Virus, Entry, Replication, Pathogenesis, virologists, viral, infectious diseases, membrane, proteins, antibodies, innate, immunity, biochemistry
Webseite	http://www.keystonesymposia.org/12X7
Verwandte Fachgebiete	Biologie; Medizin (allgem.)
7.Keystone Symposia: Nuclear Receptor Matrix: Reloaded
Termin	15. Apr 2012 → 20. Apr 2012	[ID=428054]
Ort	Whistler, BC, Kanada
Zusammenfassung	Nuclear receptors (NRs) represent a large superfamily of transcription factors that function as ligand-dependent sensors for a diverse set of fat-soluble hormones, vitamins and dietary lipids. Together, NRs govern expression of genes involved in a broad range of reproductive, developmental, metabolic and immune response programs. For this reason, NRs have been investigated for over 20 years as promising targets for drugs to treat a multitude of therapeutic indices, including cancer, diabetes, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. However, despite the success of numerous NR-based therapies, there remain significant hurdles exploiting NRs to develop newer classes of therapies that achieve targeted benefits with reduced side effects. Thus, understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern NR action has become an important new strategy for evaluating the role of NRs in health and disease. This ?reloaded? effort is now beginning to produce exciting new avenues of research in the field. This meeting will bring together a key group of junior and senior investigators that are exploring these new directions and provide participants with a matrix of unique possibilities for them to investigate in both academic and pharmaceutical laboratory settings.
Themen	Keystone Symposia, Nuclear, Receptor, Matrix, nucleus, cell, biology
Webseite	http://www.keystonesymposia.org/12D3
Verwandte Fachgebiete	Biologie; Molekularbiologie

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Stand vom 17. August 2011