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European Molecular Biology Organization – EMBO

Department of Experimental Biology, Faculty of Medicine of the University of Porto

The Essential Molecular Biology course covers the fundamental principles and techniques used in experimental research in the area of Molecular Biology. Essentially practical in nature, it aims at the learning of current genomics and proteomics techniques, as well as the acquisition of skills in laboratory experimentation required for scientific research in Biomedicine. An exciting way to learn the essential genomics and proteomics techniques used in experimental research in biomedicine: hands-on, practical, intensive.

Tél.: [+351 220426779];     Email.: laimm@med.up.pt

Molecular biology, genomics, proteomics, hands-on, laboratory work, practical

Focus in precision biochemistry and precision medicine

Fusion Conferences

We have reached a fascinating point in our research on the ubiquitin system’s function, physiology and roles in disease. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable degradation of proteins in the cytosol by the proteasome. It was much later that it was discovered that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives a multitude of signalling pathways the required plasticity to initiate but also to limit their signalling output in an exquisitely controlled manner. Whereas certain signalling-related functions employ ubiquitin’s proteasome-targeting function, e.g. the activation of NF-kB following degradation of I-kB, most signalling-related functions of the ubiquitin system are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.