PA-2020

Detailed agenda

Tuesday, September 29th, 2020
13:15 - 13:20
Opening Address
13:20 - 13:30
Welcome and Introduction
13:30 - 15:30
Session: Session I
13:30
PA levels in food: Current situation and perspectives
Patrick P.J. Mulder, Wageningen (NL)
14:00
Metabolism an kinetics as key determinants in PA toxicity
Ivonne Rietjens, Wageningen (NL)
14:30
Identification and quantification of PA metabolites: consequences for risk assessment
Anja These, Berlin (D)
15:00
Application of cutting edge research tools to PA risk assessment
Catherine Mahony, Egham (GB)
15:30 - 16:00
Coffee break
16:00 - 17:30
Session: Session II
16:00
Experiences with the Code of Practice designed for PA management
Barbara Steinhoff, Bonn (D)
16:30
Regulatory perspectives of PA contamination in herbal medicinal products
Jacqueline Wiesner, Bonn (D)
17:00
Risk assessment of PA occurrence in phytomedicine: A European perspective
Heid Foth, Halle (D)
Wednesday, September 30th, 2020
13:30 - 15:30
Session: Session III
13:30
Pyrrolizidine alkaloid secondary pyrrolic metabolites construct multiple activation pathways leading to DNA adduct formation and potential liver tumor initiation
Peter Fu, Jefferson (AR, USA)
14:00
Dose-response of alkylation-induced genotoxicity - implications für PA  
Jörg Fahrer, Kaiserslautern (D)
14:30
Mechanism and potential toxic impact of pyrrolizidine alkaloid N-oxides
Ge Lin, Hongkong (HK)
15:00
New aspects impacting genotoxic potency of PAs and PA N-oxides
Stefan Pfuhler, Cincinnati (OH, USA)
15:30 - 16:00
Coffee break
16:00 - 18:00
Session: Session IV
16:00
Bioassay-directed analysis approach for the identification of relvant pyrrolizidine alkaloids
Ad Peijnenburg, Wageningen (NL)
16:30
Health risks of 1,2-unsaturated PAs in foods
Benjamin Sachse, Berlin (D)
17:00
Developments in mixture risk assessment in Europe
Jacob van Klaveren, Utrecht (NL)
17:30
The bad ones and the not so bad ones? How to assess the carcinogenic risk from PA exposure?
Dieter Schrenk, Kaiserslautern (D)
18:00 - 18:15
Summary and Farewell

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