Meetings/Workshops on Genomics and Bioinformatics in Canada

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1
Keystone Symposia: Chromatin Architecture and Chromosome Organization
23 Mar 2018 - 27 Mar 2018 • Whistler, British Columbia, Canada
Abstract:
Understanding the principles governing genome regulation is one of the major challenges now facing biomedical research in the 21st century. Deciphering structure-activity relationships of the genome and its partners in the context of the cell nucleus is a necessary step for understanding the basis of development and disease, as well as for the elaboration of strategies against particular forms of cancers and genetic disorders. The genome is not a linear molecule of DNA randomly distributed in the nucleus, but exists as a three-dimensional (3D) object, intricately folded and packaged, structured around nuclear bodies and landmarks, acted upon by countless force-generating nano-machines and remodeling factors. With the recent advances that have been made in microscopy, biochemistry and modeling, the time is ripe to fully address the study of the genome in 3D space and time and consider it as a complex, dynamic biological system. Up until recently, many of the scientists involved in chromatin biology and epigenetics would attend meetings dedicated to this topic and would not necessarily interface with scientists using advanced imaging or physical and mathematical modeling approaches. This meeting will bring together some of the world’s leading experts and emerging talents at the interface of these topics to explore chromosome architecture and its dynamic relationship with genome function. Specifically, it will explore: 1) Chromatin structure and how this relates to gene expression and genome functions such as DNA replication and repair; 2) Chromosome conformation and the new insights into genome organization that have emerged using new technologies; 3) The nature of the chromatin partners (proteins, RNAs) that underlie chromatin folding and functions and their dynamic relationships in different contexts (cell cycle, development, environmentally induced changes, etc.); 4) Emerging imaging technologies and microscopy and the answers they are bringing to the dynamics of chromatin and chromosome architecture; and 5) New physical and mathematical modeling approaches to further our understanding of the principles governing chromatin architecture. This symposium is being held jointly with "Gene Control in Development and Disease."
Contact:
Attendee Services;     Phone: [970.262.1230];     Email: info@keystonesymposia.org
Topics:
RNAs, cancer, molecular biology, chromatin structure, genetics, genomics
Event listing ID:
988595
Related subject(s):
2
Keystone Symposia: Gene Control in Development and Disease
23 Mar 2018 - 27 Mar 2018 • Whistler, British Columbia, Canada
Abstract:
Proper control of gene expression is important for all fundamental cellular and organismal processes. With advancements in technology and genetics, researchers are now able to use a combination of genetic, biochemical and computational methods to investigate gene control in healthy cells, as well as to discern what happens when these controls go awry in disease. Learning how gene expression programs are regulated is essential to understanding the control of cell state and its impact on disease development. Multiple levels of gene regulation including basic transcriptional controls, enhancers, epigenetics and the role of phase separation in transcriptional control will be addressed. The goal of this conference is to share new insights into gene control in health and disease and to discuss advances that are being made in disease therapy based on gene control therapeutics. This symposium is being held jointly with "Chromatin Architecture and Chromosome Organization."
Contact:
Attendee Services;     Phone: [970.262.1230];     Email: info@keystonesymposia.org
Topics:
gene therapy, transcription, genetics, genomics, development, molecular biology
Event listing ID:
988583
Related subject(s):

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AIP Conference Proceedings
Last updated: 31 January 2018