The Mona Symposium – Natural Products and Medicinal Chemistry has been organised on a biennial basis since 1966. The 27th staging is scheduled for January 8-11, 2018 and will continue a strong tradition of bringing together a diverse panel of speakers to present on recent advances in Biosynthesis, Marine and Terrestrial Natural Products and Synthetic Methodology. The meeting will be held at the University of the West Indies, Mona which is centrally located in warm and sunny Kingston, Jamaica. The relaxed atmosphere of the Mona Campus fosters an environment for stimulating scientific exchange as well as offers opportunities for recreation and a variety of social activities. Our speakers for 2018 include: Amos B. Smith III, University of Pennsylvania; Nicholas Oberlies, The University of North Carolina at Greensboro; David Craik, The University of Queensland; Karine Auclair, McGill University; Rebecca Goss, University of St Andrews; Hiroyoki Osada, Director Chemical Biology Research Group; Ken Ohmori, Tokyo Institute of Technology; Chris Willis, University of Bristol; Michael Burkart, University of California- San Diego and Wilfred A. van der Donk, University of Illinois. The deadline to submit abstracts is November 30,2017.