Konferenzen zum Thema Molekularbiologie in Italien

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1
Neural Stem Cells: Development and Brain Repair
20. Mai 2017 - 27. Mai 2017 • Siena, Italien
Zusammenfassung:
A number of neurological diseases are characterized by the loss of individual neuronal subtypes and/or specialized glial cells. The ongoing effort is to understand the underlying pathophysiology in an attempt to identify suitable drug targets. Opportunities have emerged within the stem cell field. Unprecedented advances have been made in our understanding of stem cells and through them much can be learned about the physiology and pathophysiology of the cells that degenerate in different brain disorders with the ultimate goal of delivering therapeutically relevant stem cells that could ameliorate the clinical outcome. The Advanced Course will bring together a collection of investigators who are at the forefront of their field and will showcase research at the frontiers of neural stem cells for neurorepair.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
857912
Verwandte Fachgebiete:
2
Learning and Memory: Cellular and Molecular Mechanisms
28. Mai 2017 - 04. Jun 2017 • Siena, Italien
Zusammenfassung:
Recent ground-breaking developments in neuroscience, such as optogenetics, in vivo 2-photon confocal microscopy, head mounted microscopes, powerful new developments in modeling, behavioral neuroscience approaches, and sophisticated brain imaging tools, have changed dramatically studies of memory. Most importantly, these developments have fostered interdisciplinary studies that led to integrated molecular, cellular, systems, cognitive and behavioral explanations of how memories are allocated, formed, consolidated, reconsolidated and retrieved. These studies have also led to mechanistic cross-disciplinary studies of memory disorders, which in some cases led to the development of targeted treatments that are changing how we imagine treating the considerable health burden associated with this large class of conditions.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
857922
3
International School of Crystallography 50th Course: Integrative Structural Biology
02. Jun 2017 - 11. Jun 2017 • Erice (Sicily), Italien
4
2nd DNA Replication as a Source of DNA Damage Conference
03. Jul 2017 - 06. Jul 2017 • Rom, Italien
Zusammenfassung:
The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing.
Kontakt:
Laura Trundle;     Email: laura@fusion-conferences.com
Themen:
DNA Replication, DNA Damage, Cancer, Ageing
Eintrags-ID:
814060
Verwandte Fachgebiete:
5
Neuroepigenetics and Epitranscriptomics
19. Aug 2017 - 26. Aug 2017 • Siena, Italien
Zusammenfassung:
Many cellular constituents in the human brain permanently exit from the cell cycle during pre- or early postnatal development, but little is known about epigenetic regulation of neuronal and glial epigenomes during maturation and aging, including changes in cognitive and psychiatric disease. Normal brain development and function is dependent on highly regulated mechanisms governing DNA cytosine methylation and hydroxymethylation, and probably more than 100 residue-specific histone modifications associated with gene expression and silencing and various other functional chromatin states. Equally important is the 3-dimensional organization of the chromosomal material inside the cell nucleus, commonly referred to as the ‘3D Genome’, with chromosomal loopings potentially bypassing hundreds of kilobases on the linear genome to enable promoter-enhancer interactions and other mechanisms important for transcriptional regulation. Combined exploration of epigenomic and 3D genome chromosomal conformation maps maps is likely to illuminate the role of regulatory non-coding sequences in neuropsychiatric disease.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
868383
6
Synaptic and Structural Plasticity
26. Aug 2017 - 02. Sep 2017 • Siena, Italien
Zusammenfassung:
Different forms of synaptic plasticity occurring at the molecular, cellular and circuit level are the focus of this Advanced Course. The Course will start with critical analysis of the evolution of the study of various forms of long-term potentiation and long-term depression and what is generally accepted about their basic mechanisms, including a discussion of modern approaches to understanding the mechanisms and functions of synaptic plasticity. A wide range of areas will be covered, including: (a) the molecular mechanisms underlying different forms of short-term synaptic facilitation and depression that last no more than a few minutes and are typically mediated by presynaptic mechanisms that alter neurotransmitter release (b) the function of key postsynaptic proteins found in the postsynaptic density as well as the role of neurotransmitter receptor regulation during long-term synaptic and experience-dependent plasticity (c) the methodological approaches that have been recently developed to measure the dynamic localization of synaptic elements at nanoscale resolution and how these nanoscale morphological and functional properties regulate synapses (d) the role of neurogenesis throughout life as a crucial mechanism underlying learning-induced circuits in the dentate gyrus and the olfactory bulb (e) how these forms of plasticity integrate to result in the restructuring of entire neuronal circuits. Participation in the Advanced Course will provide an essential conceptual and methodological framework for anyone intending to pursue rigorous research. The advantages and disadvantages of each method, preparation and recording technique are considered in relation to the specific scientific questions being asked. The Advanced Course will not only develop participants’ skill but will also provide plenty of time for informal gatherings with some of the world leaders in synaptic plasticity, designed to foster brainstorming across different disciplines.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
868371
7
Cognitive Decine and Aging
01. Sep 2017 - 08. Sep 2017 • Siena, Italien
Zusammenfassung:
Age is the greatest risk factor for multiple neurodegenerative diseases. In that context, the prevailing perception of the aging brain is of linear decline across multiple systems. A diametrically different perspective is that the aging brain is a dynamic adaptive organ that initiates multiple survival systems throughout the aging process. While these adaptations in the aging brain are for the majority of persons beneficial, they can, in vulnerable populations, lead to increased risk of neurodegenerative disease. The systems biology of transition states in normal aging and neurodegeneration provides insights into mechanisms of disease risk and disease progression. Risk of multiple neurodegenerative diseases can emerge during neuroendocrine transitions of aging when gene networks undergo shifts in activation and expression. These risk networks underlie the prodromal phase of neurodegenerative disease. Later, transition states typify the progressive nature of multiple neurodegenerative diseases. Risk for and progression of Alzheimer’s disease are exemplars of both risk that can emerge during neuroendocrine transitions and the transition states of disease progression.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
868436
Verwandte Fachgebiete:
8
Single Cell Omics
17. Sep 2017 - 24. Sep 2017 • Siena, Italien
Zusammenfassung:
Neuroscience has entered a critical phase, with several international large-scale efforts devoted to the analysis and understanding of brain function. Studies exploiting new technologies for defining the connections in the brain, driving neuronal activity and modeling of neuronal processing are each hampered by our incomplete knowledge of the brain’s constituent parts. Fortunately, a bevy of single cell analyses are now being deployed to better understand the cells that constitute the functioning nervous system. These approaches offer insights into how cells function individually as the building blocks for understanding how they work in ensemble to create functional pathways. A set of emerging tools are available to assess the molecular and cell biology of single cells, including genomic analyses of somatic mutations, epigenomics to explain the influence of the environment upon genome expression, and transcriptomics to gain insight into the capacity of a cell to synthesize proteins and modulate its environment. Powerful technologies permit a variety of cell constituents to be addressed, including proteins, post-translational modifications, peptides and metabolites. Novel biosensors offer parallel analyses of cellular physiological states, reporting on the pH, membrane voltage and metabolic state. Multiplexed together, such methodologies offer a far more complete biological understanding than the more typical gene expression analyses, providing a rich picture of each single cell’s biology in their normal context – information needed to fully interpret the meaning of results from transcriptomics and proteomics studies.This Advanced Course is designed to provide the foundational knowledge needed to critically evaluate the design and execution of single cell omic studies, through daily lectures by the Faculty, critical reading of papers and extensive didactic discussion sessions. In the sessions, discussion will focus on the proper framing of scientific questions to best utilize these techniques, the limitations and advantages of each technique, and what the data can tell us about neuronal function.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
868413
9
The Neuroscience of Obesity
17. Sep 2017 - 24. Sep 2017 • Siena, Italien
Zusammenfassung:
Significant progress has been made in recent years in the understanding the role of the nervous system in obesity. Not only several different neuronal pathways, neurotransmitters and hormones have been identified as major players in the regulation of feeding and body weight, bu also energy balance in mammals is controlled by a complex network of interacting feedback mechanisms that involve peripheral organs in addition to higher brain centers. This Advanced Course will provide conceptual- and cutting edge technological framework for state-of-the-art of neuroscience on energy metabolism. The Faculty represents diverse expertise in molecular, cellular, circuit and behavioral approaches on contemporary questions regarding the role of the brain in systemic metabolism regulation and how the periphery affects complex brain functions via neuronal circuits and brain cells.
Kontakt:
Francesca Martini;     Tel.: [+39.0577.146.0003];     Email: info@nsas.it
Eintrags-ID:
868412
10
OAP Conferences — International Conference on Proteomics
06. Nov 2017 - 07. Nov 2017 • Rom, Italien
Zusammenfassung:
Open Access pub would like to invite you to the “International Conference on Proteomics” which is going to be held on November 06-07, 2017 in Rome, Italy. The conference will analyze what are the recent techniques and what are the steps to improve those techniques. We welcome you all to be a part of this event to contribute your novel research ideas into a presentation.
Kontakt:
Tel.: [1-800-520-4889];     Email: reshsarina.oap@gmail.com
Themen:
Genetics, Biochemistry, Biotechnology
Eintrags-ID:
904794
11
International Conference on Proteomics
20. Nov 2017 - 21. Nov 2017 • Rome,Italy, Italien
Kontakt:
carol smith;     Tel.: [1-800-520-4889];     Email: carolsmith.oap@gmail.com
Themen:
Genetics
Eintrags-ID:
900151

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