On June 12, 2017 Panama and China established diplomatic relations. This new step in the relation helps to enhance the opportunity for China´s investment in the country. But Panama is not like any other country. Panamá has a Canal and is a strategic node for the global maritime trade. Since 2013, China has been driving the Silk Road initiative as a way to improve global integration through commerce and to promote economic growth in Eurasia among other things. Still, the newly established relations create an opportunity to expand the initiative to Panama. This expansion could impact significantly global trade, especially in the Atlantic, and could further integration and globalization in the world. However, there are some key factors that need to be considered in order for it to work. The Belt and Road initiative encompasses not only the commercial dimension but other dimensions as well such as: Geopolitical, Security, Financial, Economic, and Cultural among others. Yet, if it works, the Belt and Road initiative will certainly have a big impact on trade, trade routes and on the future development of the world.