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This conference will present cutting-edge, multi-disciplinary research on mechanisms of learning and memory in health and disease. Particular emphasis will be given to address the questions of
How is memory stored at the molecular and neuronal circuit level?
How is memory storage affected in dementia and autism?
What are the molecular and neuronal circuits of retrieval-induced memory modulation?
How of retrieval-induced memory modulation impaired in post-traumatic stress disorder?
During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments. Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental factors and is directly influenced by tumor therapy. Indeed, therapies that aim to shape the local immune milieu and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of tumors more adequately and may therefore add substantial benefits for therapy. An absolute pre-requisite for such an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this symposium aims to gather a comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for the plasticity of both stromal and tumor/stem cells. It will bring together experts in cancer, stromal and immune cells to synthesize scientific knowledge about the phenomenon of cell plasticity within the tumor microenvironment, to define molecular and cellular pathways mediating plasticity and to propose approaches to interfere with cell plasticity for a new generation of effective therapeutic approaches in cancer and chronic injury. Importantly, it will bring together interdisciplinary groups of scientists or investigators who normally would not have an opportunity to meet (classical cancer biologists, tumor immunobiologists, stem cell experts and scientists working on stromal cells).
The objective of this meeting is to bring together leaders in the field to discuss latest advances in stem cell biology with an emphasis on transcriptional and epigenetic mechanisms of gene regulation in pluripotent and neural stem cells. It will elucidate the roles of transcriptional regulators and chromatin structure in defining stem cell identity. These presentations will be complemented by talks on experimentally induced cell fate changes during reprogramming to pluripotency and transdifferentiation into various cell lineages. We will further discuss efforts to capture distinct stem cell types and states from the preimplantation embryo including naïve human embryonic stem cells. Advances in pluripotent stem cells will be compared and contrasted with recent insights into the biology of neural stem cells, including discussions of their origin, specification and turnover. Lastly, two sessions dedicated to disease modeling and cell therapy, respectively, will highlight ongoing attempts to study and treat diseases using stem cells from the hematopoietic and neural systems. This meeting is being held jointly with
The complexity of the brain, with thousands of neuronal types, permits the development of sophisticated cognitive and behavioral repertoires. Neurogenesis, the fundamental phenomenon that creates the brain, starts early during development and continues in the adult life, shaping our networks in close association with the environment. This unique meeting will explore neurogenesis from different perspectives, bringing new insights about the fundamental mechanisms that control normal brain development and that contribute to disease situations when this process is altered. It should bring together scientists working on different aspects of neurogenesis to exchange ideas and facilitate novel collaborative projects. The pairing of the meeting will with a stem cell meeting will enhance the opportunity for interactions among researchers from different fields pursuing similar questions. This meeting is being held jointly with
Physical-chemical and chemical determinations currently employed for monitoring pollution are mainly based on qualitative and quantitative information about contaminants and freshwater quality, generally at high costs, providing indirect information and no direct biological interpretation of damage for these ecosystems. Thus, molecular biomarkers constitute a first approach for gathering information about cell damage and antioxidant response, early signals of ecosystems disorders. The main goal of the Symposium is focussed to generating debate about advantages using molecular biomarkers approach for biomonitoring ecosystems' health with respect to conventional chemical and physical-chemical methods. Thoughts must be focused about appropriateness and relevance of gathered information, nature of analysis to be done, costs and period for assays establishment during decision-making process; which allows a closer assessment of biological damage in ecosystem health introduced by pollutant sources and their environmental impact.
En el marco del IX Congreso de la Biodiversidad Caribeña se podrán enviar resúmenes para presentar en el Simposio: ACERCAMIENTO HACIA UN BIOMONITOREO SOSTENIBLE DE LA SALUD DE ECOSISTEMAS DULCEACUICOLAS SOBRE LA BASE DE BIOMARCADORES MOLECULARES DEL ESTRÉS OXIDATIVO.
Los métodos químicos que se emplean actualmente para el monitoreo de la contaminación se basan fundamentalmente en la detección cualitativa y cuantitativa de los contaminantes. Son métodos generalmente costosos y proveen información indirecta, muchas veces sin una interpretación biológica del daño sobre estos ecosistemas. En tales condiciones, los marcadores moleculares constituyen una primera aproximación en la recopilación de información sobre el daño celular y la respuesta antioxidante, señales tempranas de alteraciones en los ecosistemas. El objetivo del Simposio es explicar las ventajas del biomonitoreo de la salud de los ecosistemas dulceacuícolas con métodos bioquímicos respecto a los métodos químicos y físico-químicos convencionales sobre la base del debate acerca de la pertinencia y relevancia de la información que brindan estos métodos, tipo de análisis a realizar, costos y momento en el que se establecen los ensayos para la toma de decisiones, permitiendo así una evaluación más cercana al daño biológico que introducen las fuentes contaminantes en la salud de los ecosistemas y su impacto ambiental.
Speakers: Christa Schleper, Gordon Brown, Ian Baldwin, Jon Clardy, Michael Meyer-Herman, Manja Marz, Oliver Kurzai, Sarah O´Connor and Susan Trumbore
The concept of area-wide integrated pest management (AW-IPM), in which the total population of a pest in an area is targeted, is increasingly being considered for related genetic, biological and other pest suppression technologies. Insect movement, occurring sometimes over long distances, is generally underestimated. As a consequence, most conventional pest management is implemented locally in uncoordinated action against only segments of a pest population, resulting very often in unsustainable control. On the other hand, an AW-IPM approach involves a preventive rather than a reactive strategy, whereby all individuals of the pest population are targeted in time and space, resulting in more cost-effective and sustainable pest management.
This course will provide the participants with an overview about the basics of microscopy (light and optics, contrast techniques and imaging). The confocal part will include multicolor, 3D- and time lapse imaging as well as spectral imaging, photobleaching (FRAP, FLIP, FLAP) and photoactivation techniques. Basic image analysis tools including measurement functions, colocalisation and spectral unmixing as well as 3D/4D image processing will be covered, both in theory and practice. The course will combine lectures with intense daily hands-on practices followed by discussions.
To merge these different research areas “Biodiversity of Foodborne Microbes” has been chosen as the common theme of the conference. Participants will be offered an excellent programme, demonstrating scientific diversity and subject depth. This will be achieved by utilizing the scientific expertise of the selected national and international committees, including the members of the International Committee on Food Microbiology and Hygiene (ICFMH).
Stand vom 27. November 2016