The objective of the Conference is to provide a forum to exchange experience and views among professionals in the nuclear industry in the development and use of Best Estimate Plus Uncertainty (BEPU) methods in safety analyses and design of nuclear installations. The Conference will address a broader spectrum of methods (in respect to the past when the focus was primarily on thermal-hydraulic system codes) and also include reactor physics, fuel performance, severe accidents, fission product transport and chemistry, dispersion, etc. Generally speaking, the multi-physics of the problems will be addressed, as well as the numerics and computational platforms, including parallel computing. The BEPU 2018 will include CFD codes, simulators and problems of modeling I&C in systems safety analyses. Another topic to be addressed is the problem of the verification and validation of methods with the supporting experimental programs. The Conference will consider applications mainly to Light Water Reactors including Small Modular Reactors, even though the liquid metal cooled, gas cooled, molten salt (cooled and homogeneous reactors) and other types that are in development will be included as well as the research reactors.