Conférences - Génomique et bio-informatique - Canada

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1
Keystone Symposia: Genome Engineering - From Mechanisms to Therapies
19 fév 2019 - 23 fév 2019 • Victoria, BC, Canada
Résumé:
The use of programmable nucleases such as CRISPR-Cas systems, ZFNs and TALENs has revolutionized cell biology by providing the ability to manipulate specific genetic and epigenetic states within living cells. These systems have been broadly applied as tools in research settings and increasingly are being used to develop improved models of disease and engineer cells for therapeutic purposes. Together with other DNA-modifying systems such as recombinases, integrases and transposases, it is now possible to introduce mutations that will model human disease, build complex synthetic signaling networks to perform regulated functions, and design cells to target specific disease states. Improvements to the methods involved requires understanding enzyme structures and mechanisms and how they intersect with cellular DNA repair systems. The intersection of this basic science with engineering approaches and improved cellular models is revolutionizing our understanding and treatment of human disease. The goal of this Keystone Symposia conference is to bring together those developing and studying genome engineering tools with groups who are applying them to build new disease models, identify disease mechanisms and drug targets, and develop cell-based therapeutics and genetic medicines.
Contact:
Attendee Services;     Tél.: [970.262.1230];     Email.: info@keystonesymposia.org
Sujets:
genetics, genomics, CRISPR-Cas systems, DNA, gene editing, genome engineering, basic research, technologies, molecular biology
Identifiant de l'évènement:
1156330
Sujets apparentés:
2
Keystone Symposia: Epigenetics and Human Disease
17 mar 2019 - 21 mar 2019 • Banff, Alberta, Canada
Résumé:
Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states. This conference, held jointly with the “3D Genome” conference, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models.
Contact:
Attendee Services;     Tél.: [970.262.1230];     Email.: info@keystonesymposia.org
Sujets:
DNA, noncoding RNAs, chromatin, genetics, genomics, molecular biology, cancer
Identifiant de l'évènement:
1156345
Sujets apparentés:
3
Keystone Symposia: 3D Genome - Gene Regulation and Disease
17 mar 2019 - 21 mar 2019 • Banff, Alberta, Canada
Résumé:
Transcription of the eukaryotic genome is not only driven by the cis regulatory elements embedded in the linear DNA sequence but also by the way chromosomes fold in the three-dimensional (3D) nuclear space. Growing evidence has pointed to a key role of the 3D genome architecture in gene regulation and human disease; however, the details of dynamic chromatin organization in different cell types remain opaque. Additionally, how chromatin organization shapes the gene regulatory program and influence disease pathogenesis has not been fully elucidated. The major objective of this conference is to accelerate the study of 3D genome organization; particularly with regard to gene regulation and human disease.
Contact:
Attendee Services;     Tél.: [970.262.1230];     Email.: info@keystonesymposia.org
Sujets:
molecular biology, genetics, genomics, 3D genome architecture, epigenomics, computational biology
Identifiant de l'évènement:
1156333
4
19w5221 — Emerging Statistical Challenges and Methods for Analysis of Human Microbiome Data
15 sep 2019 - 20 sep 2019 • Banff, Alberta, Canada
Identifiant de l'évènement:
1138573

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Dernière mise jour: 06 Décembre 2018