joint with the meeting on Integrating Metabolism and Immunity
Cell death has long been known to be an important instigator of inflammation in sterile injury, as well as an amplifying factor in infection-associated inflammation, but the specific molecules underpinning this remain obscure. Understanding how dead and dying cells initiate and escalate inflammation has important implications for our understanding and treatment of autoinflammatory and infectious diseases. This meeting will explore current knowledge concerning the cellular constituents that drive inflammation (i.e., damage-associated molecular patterns), as well as how abnormal modes of cell death, such as necrosis, necroptosis and NETosis, can perturb inflammatory outputs and responses to dying cells. In particular, the conference aims to explore gaps in our current understanding of how dead and dying cells influence inflammatory responses in disease settings and will bring together experts in two major research fields, ”cell death” and ”inflammation,” for the purpose of clarifying what the key questions and therapeutic targets are in this rapidly evolving area. Many well-known physiological drivers of cell death (e.g., TNF, TRAIL, CD95/Fas), as well as the molecules that transduce signals from these receptors (e.g., RIPKs, IAPs, TRAFs, IKKs), are also centrally involved in promoting inflammation. However, the tremendous overlap between cell death and inflammatory signaling is only becoming appreciated of late, and although it is also widely accepted that the constituents of healthy cells can drive inflammation upon release into the extracellular space, the identity of these cellular constituents is still a matter of debate. This meeting will focus on teasing out the relationships between cell death and inflammatory signaling to highlight how perturbation of either of these processes invariably impacts upon the other. This meeting will also explore the nature of the molecules that promote and modulate inflammation during cell death. The meeting will bring together scientists from diverse fields (cell death, inflammation, cancer, innate immunity) that would not normally interact, and will identify and explore the key questions and directions that will shape the future of research in this field.
Abstract & Scholarship Deadline: January 31, 2017
Abstract Deadline: March 1, 2017
Discounted Registration Deadline: March 29, 2017
Through a series of presentations from handpicked industry experts, two pre-conference workshops and an additional interactive training session, the agenda will discuss hot topics such as rapid microbiology methods (RMM), risk assessment, challenges in endotoxin recovery, environmental monitoring, sterility assurance, data integrity and much more…
Speaker Line-Up Includes: Janssen, Amgen, Takeda, Merck, Bimeda, Excellent Pharma Consulting, Roche Molecular Systems, Microrite and many more…
With the increasing appreciation of the integration between different steps of gene expression, the conference will explore the connections between translation, mRNA turnover, nonsense-mediated decay, RNA localisation, and nuclear events such as transcription and splicing. Finally, many alternatives to the classical “one message makes one protein” concept are being unraveled which increase the potential for regulation. These alternatives will be featured, as well as the role of translational regulation in diseases as diverse as cancer, neurological disorders or infectious diseases.
The conference is designed to promote interactive discussions at both the talks and poster sessions. Given the excellent line up of speakers and the meeting’s outstanding reputation, this is a ‘must’ attend for anyone interested in cutting edge research in biotechnology and bioengineering.
The conference will feature a mix of invited speakers drawn from a wide variety of backgrounds and experiences, and will bring together international basic, translational and clinical scientists and physicians from academics to industry.
Please bring this notice to the attention of any of your colleagues who may be interested in participating in the conference.
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