Organs do not function in isolation. In contrast to the majority of existing meetings that focus on individual organs (lung, pancreas, intestines, etc.), or individual pathways (FGF, WNT, Hippo, etc.), this conference offers a unique cross-organ perspective on development, homeostasis, repair, regeneration and pathogenesis. The endoderm is an ideal setting as it gives rise to the majority of our internal organs such as the thyroid, thymus, lungs, liver, pancreas, esophagus, stomach, intestine and prostate, etc. Associated with these organs is a wide spectrum of diseases, including asthma, diabetes, fibrosis, obesity, infections and cancer. This conference aims to achieve the following goals: 1) Synthesize similarities and differences of mechanisms of specification, morphogenesis, maturation, regeneration and pathogenesis across organs; 2) Use the simplicity of the developing organs to uncover complex disease mechanisms; 3) Investigate organ development and function in the context of other organs, the immune system and the nervous system; 4) Consider organ physiology and metabolism under the influence of the environment: bacteria, viruses, allergen, pollutants and circadian control; and 5) Share successful technologies across organ systems. Such a cross-sectional perspective brings together researchers across scientific disciplines who do not normally meet. The meeting will link development with physiology and help to establish a community of the next generation of researchers who will approach their scientific investigation with a broad, multi-systems view.