Close to 1 in 11 people in the world suffers from kidney disease, and the incidence is increasing, especially in the developing world. This issue was recently reviewed and emphasized in a Lancet article (Global Health Atlas). Acute and chronic kidney disease is associated with a highly significant increase in cardiovascular death, and chronic kidney disease (CKD) represents a leading cause of death in the United States. There is no cure for this disease, with current treatment strategies relying on blood pressure control through blockade of the renin-angiotensin system. Such approaches only delay the development of end-stage kidney disease and can be associated with serious side effects. Recent identification of several novel mechanisms contributing to CKD development - including vascular changes, loss of podocytes and renal epithelial cells, matrix deposition, inflammation and metabolic dysregulation - has revealed new potential therapeutic approaches for CKD. This conference will review clinical and observational studies in the kidney disease area, highlight recent advances in basic biology of kidney and kidney disease, assesses emerging strategies and agents for CKD treatment, and discuss major obstacles in drug development. The conference will also encourage collaborations among clinicians and researchers from academia and pharma= and accelerate innovation in this field. Furthermore, since more than half of kidney disease is caused by diabetes, the symposium will greatly benefit from the joint pairing with the conference on “Diabetes: Innovations, Outcomes and Personalized Therapies.”
Diabetes remains a public health challenge of epidemic proportions. Modern treatment algorithms are evolving to recommend higher focus on personalized approaches to diabetes care. However, as diabetes remains a disease characterized by excess elevation of a plasma biomarker, glucose, further refinement of our understanding of the disease and its comorbidities is required to provide optimal guidance for precision medicine. Advancement of research technologies and the ability to handle large data sets have enabled systems biology approaches to unravel different etiologies and pathophysiological consequences of diabetes. Future diabetes discovery efforts will focus on pairing knowledge about genetic risk and environmental triggers of diabetes-associated pathologies. Using deep phenome characterization and molecular network analyses diabetes, researchers will be able to launch modern translational approaches to diabetes care innovation. The objectives of the conference are to provide directional guidance for future pressure points of diabetes care, and focus on specific diabetes complications representing particular unmet needs. Further, forefront discoveries of genetic risk determinants and their molecular mechanisms will be presented together with lively debates about the translatability of such insights into novel curative therapies. This symposium is paired with "Unraveling the Secrets of Kidney Disease."
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