Conference Service Mandl

abstract: Welcome to the Decade of the Genomics Revolution! Technological advances are now enabling faster and cheaper mapping of DNA/RNA allowing genomic comparisons and accelerating genomic discoveries. Cambridge Healthtech Institute is proud to launch The X GEN Congress to enable this genomic revolution. This five conference week-long event will demonstrate the unique cross fertilization of established genomic technologies with Now-Generation Sequencing and Quantitative PCR along with exciting applications of Copy Number Variation and Epigenetics. In addition, you will learn why data is the driving force that enables discovery at Sequencing Data Storage and Analysis.

abstract: Staatliche anerkannte Fortbildungsveranstaltung für Projektleiter und BBS gemäß § 15 GenTSV In Vorträgen und Diskussionen werden aktuelle gentechnikrechtliche, biologische und technisch-organisatorische Sicherheitsaspekte behandelt. In einer Art Übersicht wird die Einbindung des EG-Rechts in nationales Recht vermittelt und neue Änderungen des europäischen und nationalen Rechts behandelt. Weiterhin werden ausgesuchte Beispiele zur Gesamtbewertung von gentechnisch veränderten Organismen vorgestellt. Im Detail werden Sicherheitsmaßnahmen für Labor und Betrieb sowie für die Freisetzung in Abhängigkeit von den Sicherheitsstufen vermittelt. Die Pflichten und Aufgaben des Projektleiters sowie des Beauftragten für die Biologische Sicherheit (BBS) werden ausführlich diskutiert. Nach Abschluss der Veranstaltung wird den Teilnehmern eine Bescheinigung erteilt

abstract: The regulation of gene expression has been studied traditionally at the level of transcription. While a few examples of translational regulation were known, they were considered interesting exceptions to the general rule of regulation at the level of RNA synthesis. However, over the last few years it has become evident that several widespread posttranscriptional, mostly cytoplasmic mechanisms have profound effects on gene expression. All of these mechanisms ultimately contribute to control protein synthesis, either directly, by affecting the rate of translation, or indirectly, by affecting the abundance of mRNA. Some of them exert a qualitative, all-or-none control, for example by complete repression or elimination of certain mRNAs, others determine the intracellular location or the cell-type in which a particular RNA is translated, and still others have a quantitative effect, controlling the amount of protein made from a certain mRNA. The analysis of some of the most exciting aspects of these cytoplasmic mechanisms of gene regulation is a major focus of this meeting.

abstract: This conference will feature an outstanding experience both scientifically and socially. Also, the oriental culture makes Beijing a fascinating and pleasant place to congregate with old colleagues and new friends to share the most important aspects of many exciting and rapid advances in peptide and protein researches.

abstract: The role of microRNA in regulating mammalian development and disease is now well established. miRNAs represent a novel class of targets for therapeutic and diagnostic development, currently not fully exploited by the pharmaceutical and biotechnology industries. Cambridge Healthtech Institute’s Sixth Annual microRNA in Human Disease and Development meeting is specifically designed to address the role of miRNA in human development and disease, and to explore the impact of this new research for drug and diagnostic development. The meeting will cover progress in identifying human miRNA, technologies used for miRNA profiling, and the latest research in linking miRNA to human disease. Opportunities for using miRNA as diagnostic biomarkers and a novel class of targets for therapeutic development will be explored.

abstract: Die analytica 2010 wird an den ersten drei Messetagen von der analytica Conference begleitet. In Symposien referieren Wissenschaftler aus aller Welt über die neuesten Trends in Analytik, Diagnostik, Molekularbiologie und Biochemie. Das Spektrum der Vorträge ist weit gefächert und umfasst analytische, diagnostische, biochemische und molekularbiologische Methoden und Verfahren.

abstract: Developments in functional genomics technologies together with the expanding concept of systems biology have led to exciting possibilities for the understanding of disease mechanisms. Following three highly successful conferences in Prague, Oslo and Innsbruck this conference will bring together world leaders in the field to discuss the challenges ahead and the technologies that will lead to novel solutions.

abstract: As Enzyme and Biocatalysis is currently experiencing a dramatic increasing, it has become a key element of the interactions between nature and society and is considered a key input for Bio-economic development. This focused event pays tribute to the growing significance of Enzyme and Biocatalysis, we cordially welcome you to join us and witness the advances in Enzyme and Biocatalysis together.

abstract: Experimental Biology is an annual meeting comprised of nearly 13,000 scientists and exhibitors representing six sponsoring societies and 18 guest societies. General fields of study include anatomy, physiology, biochemistry, molecular biology, pathology, nutrition, pharmacology and immunology.

abstract: The purpose of the BioMalPar annual conference is to bring together malaria researchers from Europe and overseas (including Africa, America, Asia and Australia) in order to present and share recent groundbreaking findings on fundamental malaria research. New insights will also be featured through the use of poster sessions. This meeting will also provide an enriched environment for researchers at all stages of their career to interact with international leaders in the field. The meeting will offer an excellent opportunity for sharing ideas and for potential development of new worldwide collaborations.

abstract: Welcome to the 4th annual RNAi & miRNA World Congress. This year's event will be held in Boston, home to many of the world's top institutions engaged in gene silencing research. The conference will be co-located with the Epigenetics World Congress and Genomics Automation Congress. Registered delegates will have access to all three meetings ensuring a very cost-effective trip. Keynote Speakers Anastasia Khvorova, CSO, RXi Pharmaceuticals Frank Slack, Professor, Department of Molecular, Cellular and Developmental Biology Yale University

abstract: Welcome to the inaugural Genomics Automation Congress, to be held in Boston, home to many of the world's top institutions engaged in genomics research. The conference will be co-located with the RNAi & miRNA World Congress and Epigenetics World Congress. Registered delegates will have access to all three Agenda Topics Sample Preparation and Storage Liquid Handling and Sample Management Next Generation Sequencing Reactions Alternative Sequencing Techniques Data Handling and Analysis

abstract: Welcome to the 2nd annual Epigenetics World Congress. This year's event will be held in Boston, home to many of the world's top institutions engaged in gene silencing research. The conference will be co-located with the RNAi & miRNA World Congress and Genomics Automation Congress. Registered delegates will have access to all three meetings ensuring a very cost-effective trip. Keynote Speaker Rudolf Jaenisch, Professor of Biology, MIT and Founding Member of the Whitehead Institute Agenda Topics Chromatin mechanism in epigenetic marking Non-coding RNA and gene silencing Parental imprinting, dosage compensation and monoallelic expression Nuclear dynamics and long-range control Epigenetic re-programming, stem cells and genome dynamics Epigenetic processes in disease, epigenomics

abstract: The conference series aims to incorporate basic, translational and clinical aspects of stem cell research into a single framework. The mechanisms that generate and maintain mammalian embryonic and tissue-specific stem cell populations will be discussed, as will the application of this knowledge to regenerative medicine and cancer biology. In particular, the role of induced pluripotentcy and cancer stem cells will be highlighted. Non-mammalian model systems will be included as they provide strong forward genetics, and also opportunities for in vivo pharmacological screening. The goal is to give participants an overview of the model systems and scientific and logistic framework involved in gaining and exploiting basic knowledge of stem cell biology.

abstract: The theme of the 2010 Summer School is the phenomenon of strong (or extreme) sequence conservation, which will be explored from a quantitative and multidisciplinary perspective, and connections forged with parts of biology outside of genomics.

Sequence conservation forms the basis of comparative genomics, has already played a pivotal role in biology and medicine, and is likely to become increasingly important in the eras of abundant sequence data and the personalized genome. Ultra-conservation has led to a broad appreciation of the need for a reevaluation of how the action of selection is inferred from sequence comparison. It has raised basic questions about the character of "neutral drift," calling for new quantitative developments that may be facilitated by the cultures of mathematics, physics, computer science, and engineering; however, this pursuit - and the interpretation of genome sequence in general - ought to be firmly grounded in its biological context.

With a multitude of whole-genome sequences now publicly available, ultra-conservation is trivial to exhibit, but so far difficult to explain. Therefore it represents an ideal topic for a combined Summer School and Workshop, where the phenomenon can be appreciated by participants of diverse backgrounds, who can then bring their own perspectives to bear on the problem.

abstract: Microtubules are of fundamental importance for an extraordinary variety of essential processes in all eukaryotic cells. In the 1980s, advances in light microscopy and the discovery of motor proteins catalyzed the expansion of microtubule cytoskeleton research. In the 1990s the discovery of GFP revolutionized the visualization of dynamic cytoskeletal processes inside cells. Over the years and especially recently due to the advent of proteomics, many nteractors of microtubules have been identified and we are approaching an exciting phase where complete knowledge of the components of the microtubule cytoskeleton appears within reach. Therefore, the focus of microtubule cytoskeleton research is moving from identification of components, their characterization in isolation, the consequences of loss of function for intracellular organization and dynamics towards a truly mechanistic description of the entire microtubule system and its regulation.

To achieve a systems-wide understanding of microtubule cytoskeleton behaviour requires a combination of different disciplines including biochemistry, biophysics, structural biology and mathematical modeling, and to exchange concepts developed in different scientific communities like in cell and developmental biology.

This conference aims at providing an overview of contemporary microtubule cytoskeleton research at all complexity levels, from atomic resolution to entire organisms and will be structured as follows:

(1) Molecules interacting with microtubules;
(2) Complex microtubule arrays and cell architecture;
(3) Microtubules in developmental processes and in differentiated structures.

The main objective of the conference is to bring together established scientists with young researchers from all over the world that have recently made exciting contributions to the microtubule field. The broad spectrum of interdisciplinary research approaches that will be represented will provide a unique platform and create a stimulating atmosphere encouraging not only the exchange of new discoveries, but also of novel emerging concepts beyond the limits of traditional disciplines.

abstract: Research on C. elegans plays an influential role across biology and has been at the forefront of genetics. Genetic analyses in C. elegans have led to advances in understanding many processes conserved throughout the animal kingdom, including establishment of cell polarity, developmental patterning, cell death, RNA interference, ageing, axon pathfinding, neuronal signaling and many others. Evidence of the impact of C. elegans research is the award of three Nobel prizes and a Lasker Award.

Two types of meetings focus on C. elegans research. The International C. elegans meeting, organised once every two years in the USA, covers all aspects of C. elegans research. The large size (over 2000 attendees) and diversity of the International meeting does not allow easy discussion or interactions among groups who share interest in particular research areas. To fill this gap, C. elegans “Topic meetings” are held in alternate years with the International meetings. These are focused meetings on particular aspects of C. elegans biology. Topic meetings provide a vibrant and exciting arena for discussion of current research, and the sharing of new ideas, methods, and reagents.

abstract: Challenges in Organic Chemistry and Chemical Biology (ISACS1) is the 1st International Symposium on Advancing the Chemical Sciences (ISACS) – the inaugural event in a significant new global symposia series supporting the launch of the new RSC flagship journal, Chemical Science.

abstract: Welcome to the third annual AgriGenomics World Congress which will be held in Brussels the administrative centre of the European Union. This year's coverage has been expanded to include advances in both plant and animal genomics. AgriGenomics is the detailed study of the genetic makeup of plants and how all the genes work together to produce the crop. Recently there has been great interest in genetically engineering plants to optimize yields and their use in bio-fuels. There is also focus on the alteration of certain genes to increase plant resistance towards disease and infection. So, now is a good time for scientists, business people, bio-ethicists and patent experts from around the globe to come together and catch up with the latest developments in this fast expanding field. Keynote Speakers Martin B Dickman, Professor and Director Institute for Plant Genomics and Biotechnology Jim Dunwell, Professor University of Reading Steve Kemp, Professor, University of Liverpool

abstract: The mission of this congress is to initiate a sustainable platform for exchanging up-to-the-minute upstream and downstream achievements, industrial needs and research opportunities of industrial biotechnology fields in Asia Pacific Rim.

abstract: ICCMB2 aims to bring together scientists/researchers, engineers and scholars from varied academic and industrial backgrounds for a session of open sharing and learning of state-of-the-art knowledge and breakthroughs in emerging bioengineering areas. The conference, through its programme, also seeks to reflect and address new challenges that come with new knowledge in bioengineering today. Prominent plenary speakers from globally renowned institutions in the United States, Europe and Asia Pacific will be featured in this conference, thus providing a platform for conference participants to interact and network with leading experts in the biomedical science and bioengineering fields. Active participation from invited chemical, biomedical, biotechnology and healthcare companies in this conference is also expected to generate productive cross-fertilization of ideas between industry and academia.

abstract: The meeting aims to facilitate the worldwide advancement of neurochemistry and related neuroscience disciplines, foster the education and development of neurochemists, particularly of young and emerging investigators disseminate information about neurochemistry and neurochemists' activities throughout the world.

abstract: Vererbbare Unterschiede zwischen Lebewesen entstehen nicht nur, weil die Gensequenzen sich unterscheiden, sondern auch, weil die gleiche Erbinformation in verschiedenen Zellen und Geweben unterschiedlich abgelesen wird. Abweichende Merkmale entstehen zum Beispiel, weil das gleiche Gen in einem Organismus mehr, im anderen weniger aktiv ist. Die Epigenetik beschäftigt sich mit den biologischen Grundlagen und molekularen Zusammenhängen dieser vererbbaren Veränderung der Genauslesung. Auf der Ebene des Chromatins vererbt die Zelle diese Kontrolle über das Ablesen der Gene über biochemische Veränderung der Chromatinstruktur z.B. Methylierung bestimmter DNA Elemente oder definierte Muster unterschiedlicher Histonmodifizierungen. Epigenetische Effekte spielen bei der Zelldifferenzierung, bei der Entwicklung des Embryos, aber auch wenn Zellen sich krebsartig verändern eine zentrale Rolle. Das Seminar behandelt folgende Themen: •Vermittlung der zellulären, molekularbiologischen und biochemischen Grundlagen der Epigenetik •Epigenetik was ist das? – ein historischer Einblick •Chromatinveränderungen als molekulare Basis der Epigenetik: DNA-Methylierung, Histon Modifizierungen, Histon Varianten und Chromatin remodelling •Epigenetische Regulationsmechanismen und Signaltransduktionswege •Zentrale Methoden epigenetischer Forschung •Epigenetische Phänomene (u.a. imprinting, dosage compensation, Stammzellen) •Epigenetik von Krankheiten, insbesondere Krebs Zielgruppe Technische und wissenschaftliche Mitarbeiterinnen und Mitarbeiter mit soliden Grundkenntnissen in der Molekular- und Zellbiologie. Termin PA4631 Kursbeginn (am ersten Tag) 9:00 Uhr Kursende (am letzten Tag) ca. 15:30 Uhr Die Teilnahmegebühr beträgt für den zweitägigen Kurs 649,- € Um ein optimales Lernklima zu gewährleisten, ist die Teilnehmerzahl auf maximal 12 Personen begrenzt.

abstract: The International Study Group for Systems Biology is a collective of international researchers interested in advancing the biological sciences through exploring the interplay between theory and experiment. The general theme of the meeting is theoretical approaches to understanding the behaviour of cell systems, particularly transport, metabolism and signal transduction.

abstract: Welcome to the inaugural Epigenetics Europe conference and exhibition. This year's event will take place in the dynamic city of Dublin, economic and cultural centre of Ireland. The conference will be co-located with RNAi & miRNA Europe, Advances in qPCR and Genomics Automation Europe. Registered delegates will have access to all four meetings ensuring a very cost-effective trip. Keynote Speaker Manel Esteller, Director Epigenetics Laboratory Spanish National Cancer Center (CNIO) Agenda Topics Chromatin mechanism in epigenetic marking Non-coding RNA and gene silencing Parental imprinting, dosage compensation and monoallelic expression Nuclear dynamics and long-range control Epigenetic re-programming, stem cells and genome dynamics Epigenetic processes in disease, epigenomics

abstract: Welcome to the inaugural Genomics Automation Europe conference and exhibition. This year's event will take place in the dynamic city of Dublin, economic and cultural centre of Ireland. The conference will be co-located with RNAi & miRNA Europe, Advances in qPCR and Epigenetics Europe. Registered delegates will have access to all four meetings ensuring a very cost-effective trip. Keynote Speaker Wilhelm Ansorge, Professor, EPFL ETH Lausanne Agenda Topics Sample Preparation and Storage Liquid Handling and Sample Management Next Generation Sequencing Reactions Alternative Sequencing Techniques Data Handling and Analysis

abstract: Wellcome Trust/Biochemical Society

abstract: World Congress of Cellular and Molecular Biology

abstract: Dieser Kurs richtet sich an Anwender, die im präparativen Umfeld Biomoleküle trennen und aufreinigen wollen. Es werden neben der Methodenentwicklung zur Trennung von Biomolekülen und der Verknüpfung von Methoden auch der Umgang mit präparativen Säulen und Systemen, sowie das Reinigen von chromatographischen Medien besprochen.

abstract: Die Sequenzierung von DNA ist heute in vielen Laboren tägliches Geschäft geworden. Im Zeitalter der individuellen Genomprojekte und Mega-Sequenziercenter ist es wichtig zu wissen, was kann ich selbst sequenzieren, was gebe ich außer Haus, was ist Routine und was erfordert mehr Sorgfalt, die ich selbst kontrollieren möchte. Der Kurs stellt Ihnen die historische Entwicklung des DNA-Sequenzierens dar, verweist auf diejenigen alten Methoden die heute noch ihre Berechtigung haben und erläutert die Möglichkeiten moderner HTS-Sequenziercenter. Er bereitet Sie vor, eine eigene Sequenziereinheit aufzubauen bzw. anfallende Probleme mit schwierigen Sequenzierproben zu bewältigen. Der Kurs konzentriert sich auf die Sequenzierung von Plasmiden und PCR-Produkten und Sie bearbeiten den gesamten Prozess von der template-Präparation bis zur Auswertung der Sequenzen mit gängigen Softwarepaketen und Internet-Datenbanken. Im theoretischen Teil werden unter anderem folgende Themen behandelt: •Grundlagen der DNA-Sequenzierung •Verfahren und Geräte •Methoden zur Präparation und Reinigung von Sequenzier-Template und Probenversand •Tricks und Tipps zum Sequenzieren schwieriger templates •Auswertung der Rohdaten und Analyse der DNA-Sequenzen Der Praxisteil umfasst: •Primer removal und Mengenbestimmung der template-Menge •Ansatz einer Sequenzierungsreaktion •Bedienung eines Kapillar-Sequenzierers am Beispiel des CEQ 8000 •Auswertung mit dem Programm TraceEditPro Zielgruppe Technische und wissenschaftliche Mitarbeiterinnen und Mitarbeiter mit Grundkenntnissen in der Molekularbiologie. Termin PA4641 Kursbeginn 9:30 Uhr Kursende ca. 16:00 Uhr Teilnahmegebühr Die Teilnahmegebühr beträgt für den zweitägigen Kurs Preis 649,- € Um ein optimales Lernklima zu gewährleisten, ist die Teilnehmerzahl auf maximal 8 Personen begrenzt.

abstract: We are pleased to announce our next Science and Society conference on 5-6 November 2010 at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. This well-established conference series brings together a wide range of scientists, philosophers, science communicators, policy makers, and members of the public in engaging debate.

In total, four sessions with keynote talks and panel discussions are planned for the two days at the 2010 conference. The first day will be set aside for presenting and discussing questions relevant to the evolution of sexual reproduction, as well as to the development of sex specific traits. For this purpose we are inviting leading scientists to present their field of research, including their own work, to a mixed audience of scientists and non-scientists. Talks in each session will be followed by panel discussions around questions relating to the difference between the sexes from various perspectives.

In the first session of the second day at the meeting the attention will turn to comparative research on sex differences in brain and behavior of various species. Finally, in the fourth and the last session of the conference we will reexamine the relationship between innate versus acquired sexual characteristics in humans, and attempt to assess some familiar questions of differences between the sexes in the light of new knowledge emerging from the life sciences in recent years. As with the past EMBL/EMBO Science and Society conferences, our overall aim is to promote a constructive dialogue between a wide range of professionals and members of the public.

abstract: This satellite to the 2010 meeting of the Society for Neuroscience is a joint venture between Neuropharmacology and NC-IUPHAR that will highlight how emerging structural data are providing new insights into the molecular properties of receptors, ion channels and transporters, revolutionizing pharmacological concepts, and leading to new ideas of drug discovery and development.

abstract: In diesem Seminar werden Aufgabenstellung und einfache Problemlösung in der molekularbiologischen Diagnostik in Humangenetik und Labormedizin erläutert. Neben aktuellen Methoden der molekularen Diagnostik erhalten Sie einen fundiertes Hintergrundwissen zu Anwendungsbereichen der Nukleinsäureanalytik (DNA, RNA). Der Referent geht auf etablierte Techniken zur Isolierung von Nukleinsäuren aus verschiedensten Materialen ein (z.B. Blut oder Primärzellen des Menschen) und diskutiert die Vor- und Nachteile der unterschiedlichen Methoden. Verschiedene Varianten der Polymerase-Kettenreaktion (PCR), DNA-Sequenzierung zur Mutationsanalyse und deren Anwendung in der Labordiagnostik werden besprochen.

abstract: In diesem Seminar werden Aufgabenstellung und einfache Problemlösung in der molekularbiologischen Diagnostik in Humangenetik und Labormedizin erläutert. Neben aktuellen Methoden der molekularen Diagnostik erhalten Sie einen fundiertes Hintergrundwissen zu Anwendungsbereichen der Nukleinsäureanalytik (DNA, RNA). Der Referent geht auf etablierte Techniken zur Isolierung von Nukleinsäuren aus verschiedensten Materialen ein (z.B. Blut oder Primärzellen des Menschen) und diskutiert die Vor- und Nachteile der unterschiedlichen Methoden. Verschiedene Varianten der Polymerase-Kettenreaktion (PCR), DNA-Sequenzierung zur Mutationsanalyse und deren Anwendung in der Labordiagnostik werden besprochen.

abstract: In diesem Seminar wird der Einsatz von proteinbiochemischen und immunologischen Verfahren im analytischen Labor erläutert. Neben aktuellen biochemischen bzw. klinisch-chemischen Methoden zur Proteinanalytik erhalten Sie ein fundiertes Hintergrundwissen zu Aufbau und Eigenschaften diagnostisch relevanter Proteine. Der Referent geht auf etablierte Techniken zur qualitativen und quantitiven Bestimmung von Proteinen ein. Die Extraktion von Proteinen aus verschiedensten Materialen und der direkte bzw. indirekte Nachweis u.a. mittels Western Blot und ELISA wird erläutert.

abstract: In diesem Seminar wird der Einsatz von proteinbiochemischen und immunologischen Verfahren im analytischen Labor erläutert. Neben aktuellen biochemischen bzw. klinisch-chemischen Methoden zur Proteinanalytik erhalten Sie ein fundiertes Hintergrundwissen zu Aufbau und Eigenschaften diagnostisch relevanter Proteine. Der Referent geht auf etablierte Techniken zur qualitativen und quantitiven Bestimmung von Proteinen ein. Die Extraktion von Proteinen aus verschiedensten Materialen und der direkte bzw. indirekte Nachweis u.a. mittels Western Blot und ELISA wird erläutert.